If we understand the ‘overflow’ paradigm, we see that the logical treatment of type 2 diabetes is to empty out the train. Instead, the cell is producing as much new fat as possible to relieve the internal congestion. Can you have a normal fasting insulin level but have high insulin at other times? This is a standard test to measure the blood glucose response to a standardized amount of glucose over 2 hours. This confidential blood check for Insulin is available at more than thirty private hospitals across the UK Included in each pathology request for Insulin are a Doctors Referral, all Phlebotomy fees (your blood taken at a Private Hospital), all laboratory fees and includes our GP comments. But it’s not easy. Normal fasting insulin is between 3 to 8 uIU/mL (18 to 48 pmol/L). C-Peptide. On average, you may see a 1.5 percent A1C reduction with this medication. Where the Kraft test shines is that instead of measuring only glucose, insulin is also measured, and instead of it being a 2-hour test, it’s extended to 5 hours. Is this even possible? Fasting insulin is normal, but the peak level isn’t reached until the 2 or 3-hour mark. (Large waist, obesity, fatty liver) What part of that looks like internal starvation of cells? To see a more detailed breakdown of the different patterns with both insulin and glucose, check out the guide from Meridian Valley Lab. After the patient drank the glucose solution, blood samples will be drawn and tested for both glucose and insulin levels up to the 5-hour mark. The OGTT itself is meant diagnose T2D earlier than blood glucose by measuring the blood glucose response to a 75g load of ingested glucose. Between 1972 and 1998, Dr. Kraft measured the Insulin Response and data from 10,829 of these subjects indicated that 75% of subjects were insulin resistant. Drugs don’t do this, in general. In 1975, Kraft demonstrated five distinct insulin response patterns arising during a 3-h 100 g oral glucose tolerance test. Another measurement, called HOMA-IR, is the relationship between your fasting glucose and insulin—it tells you how much insulin your body needs in order to keep your blood glucose at a certain level. Insulin is a hormone produced by the beta cells in the pancreas. causes IR, which blocks glucose from entering the cell. According to the old ‘lock and key’ paradigm, the treatment of T2D involved hiring more subway pushers to shove even more passengers into the crowded train. Dr. Kraft was looking for diabetes mellitus and was not particularly looking for hypoglycemia. Dr. Kraft spent more than a quarter century devoted to the study of glucose metabolism and blood insulin levels – collecting data in almost 15,000 people, aged 3 to 90 years old. Too much sugar –> hyperinsulinemia –> fatty liver and IR –> hyperglycaemia. If the cell is truly resistant to insulin, DNL should decrease. Which means just like you’d check your glucose levels at 30, 60, 90 and 120 minutes, you would also check your insulin levels to see if they followed a normal response. Fasting insulin is the most important test most doctors don’t even order. It is done like OGTT, but this time, insulin levels are also tested. I took the 4 hour test at home on October 13th, 2015 and sent in the blood spot test cards to the lab in a pre-paid UPS mailer the lab provides as a part of the cost of the test. Glucose and insulin responses are both normal. It is a terrific way to reveal the dynamic between your baseline (fasting) blood sugar and the responsive hormone insulin. Read some where high fat can mask insulin sensitive . NHS Choices diabetes information; Diabetes UK; Diabetic eye occurs when high blood sugar levels damage the cells at the back of the eye known as the retina. If you’re familiar with the oral glucose tolerance test (OGTT), the Kraft test is a variation on it. Verified Purchase. Insulin resistance is a decreased ability to respond to the effects of insulin, especially by muscle and adipose (fat) tissues. Why does this happen? When we eat, glucose enters the liver cell. Watch Queue Queue. which test had the greatest number of altered cases and in what duration time. Consider our two different paradigms of insulin resistance – the ‘internal starvation’ model and the ‘overflow’ model. In addition to rising higher, insulin takes longer to come back down, not returning to baseline until about 4-5 hours after. Third way: Order an inexpensive lab test called fasting insulin. It’s like the trained athlete who can easily run 10K in 1 hour and the untrained athlete who must dig deep and use all his effort to do so. The Kraft Test. The Kraft test goes beyond the standard OGTT in two ways: It measures insulin along with glucose; Instead of only two hours, the test is extended to five hours; With these two small changes, the Kraft test gives you a staggering amount of information you won’t get from the standard OGTT. But the cell is overfilled with glucose, not empty, so there is no reduction of DNL. But what happens to insulin’s other major job to increase new fat production or DNL? Before any further testing begins, i.e. This disease of fatty liver is intimately related to the overflow problem of insulin resistance. Bisher wurde Menschen mit Diabetes geraten, Insulin je nach Typ und gemessenem Blutzuckerwert 10 bis 60 Minuten vor dem Essen zu spritzen, die schnellwirkenden Insulin-Analoga unmittelbar vor oder beim Essen. Fasting insulin is an important but often overlooked test that can help identify insulin resistance. A strong scientific evidenced base argument for applying a very sensitive test which consumers can now buy online without a medical prescription a 3 hour version with 4 insulin assays and 4 glucose Assays from LifeExtension, and see if they have increased Insulin. Here at Heads Up Health, we’re committed to helping you realize your health goals. The insulin clamp test measures how much insulin is currently circulating. Just as with the standard OGTT, your baseline glucose and insulin levels are recorded via fasting levels. This post is to report my results from taking the “Kraft Prediabetes Bloodspot Profile Test” from Meridian Valley Lab. The test requires 6, yes SIX, tests in which you have to poke your finger, or fingers and squeeze out FIVE large drops of blood on a card. But this is not normal. And remember—the official diagnostic criteria for type 2 diabetes are based on glucose measurements alone, not insulin! By closing this notification, you are consenting to the use of cookies. Let’s look at Kraft’s five patterns….. Here’s what we consider a normal insulin response to a glucose bolus in an oral glucose tolerance test. This is where the Kraft test shines. It’s not a well-known test in conventional medicine, but it’s gaining popularity among doctors who use low carb and ketogenic diets with their patients. But there’s a much deeper implication to this: This is very important. B… (HOMA-IR can help identify this situation.) High insulin has the same pathology as diabetes, without any warnings from the pathetically lagging FGB and the inadequate A1c test! Heart Tests (Conventional and Alternative) Cholesterol particle size tests; Cardiac stress test; Diagnostic tests in cardiology; Diagonal Earlobe Crease Test; Diagnostic tests in cardiology ; Cardiovascular Tests; HbA1c Testing; Rapid strep test (RST) Glucose Tolerance Test; Gensini score; RDW blood test; Training. This makes a lot of sense. This is known to occur in some long-time low carbers. We used the chi-squared test in order to check . Contains Blood Spot collection kit; Test sample can be collected at the comfort of your home; Free delivery in the UK; Customers are responsible for shipping their sample to laboratory. Kraft calls this “Pattern 1”. Insulin concentrations are sometimes used in conjunction with the glucose tolerance test (GTT). A cell works in an analogous method. Tests such as HOMA have been validated against the clamp test. It should be used with caution in people with congestive heart failure, or not be used at all. It helps the glucose which is in your blood enter your cells to be used as energy. Burn the sugar off (Intermittent Fasting). After that sample is taken, you drink the glucose solution, and then your blood glucose is measured one and two hours later. Pattern 2 – Delayed insulin peak: In response to a glucose load, the insulin level rises quickly, but it rises higher than that for the healthy person in pattern 1. According to the this theory, we still need to find the mysterious boogeyman that causes IR. This was discovered by Dr Joseph Kraft in the 1970s. Fasting insulin and glucose levels are normal, and the peak insulin level is reached at about 30 minutes. A Kraft insulin dynamics test, while expensive, is the gold standard in insulin testing. Not seeing any clear address to my pattern, except a mention that, as mentioned, my insulin/pancreas ‘may’ be exhausted some (though it rallies and all hours are indeed normal- just not the normal response to glucose load you’d expect. Instead of using 75 grams of sugar, as in the OGTT, he used 100 g. For those documents that say that these tests … After the patient drank the glucose solution, blood samples will be drawn and tested for both glucose and insulin levels up to the 5-hour mark. Insulin resistance is a condition in which the cells in your body don't respond as well to the hormone insulin.Insulin is produced by the pancreas and is important for the transportation, use and storage of glucose, the body's usual main source of energy.Insulin regulates the transport of glucose into skeletal muscles, fat tissue and the liver, where glucose is needed for energy production. Anyone with insulin resistance will often have a higher than normal fasting insulin level. If your belly hits the wall before your nose does, you are insulin-resistant. If you simply wait until blood glucose is elevated, then you have T2D, no question. Well, the man who created it was Joseph Kraft, MD. If we think that T2D is the result of internal starvation, would we expect internal starvation to look like it does? The Kraft insulin survey builds on the information provided by OGTT. The Kraft test shows you your glucose and insulin responses to an oral glucose load. (2003) Modified quantitative insulin sensitivity check index is better correlated to hyperinsulinemic glucose clamp than other fasting-based index of insulin sensitivity in different insulin-resistant states. See The Blood Code book for further insight about your result. A summary of his work is here and Prof Grant also reviews it nicely here. An intravenous glucose tolerance test can be carried out where the glucose load is given into a vein rather than by mouth but again this test tends to be used … It can also be called an “oral … Taken together, these explain why fasting glucose and hemoglobin A1c in the “normal” ranges don’t always mean someone’s in the clear with regard to insulin sensitivity and healthy glucoregulation. A Kraft Test might be a useful way to see if your are becoming insulin resistant even if your glucose levels are keeping up, for now. Two hundred and fifty-five male and female participants aged over 20 years undertook a four-hour OGTT with plasma glucose, insulin and c-peptide levels recorded. Now is the time to join forces with the CDC-recognized program to prevent or delay type 2 diabetes. By about 3 hours later, it’s back to baseline. In many people, high insulin (hyperinsulinemia) is the primary driver of chronic metabolic illness, even when blood glucose is normal. Data were obtained from records of routine medical care at St Joseph’s Hospital, Chicago, IL, USA, during 1977. Ingredients: 4 boneless pork chops 2 C. Harrisburg Party Bus Rental. Specific insulin suppression tests may also be requested in a research setting to study insulin resistance but are not generally used in a clinical setting. Keywords: hormone Created Date: 20191023150434+01'00' Insulin is a hormone made in the beta cells of the pancreas. Get regular free content delivered straight to your inbox. This site uses Akismet to reduce spam. The most promising research has been based around insulin response patterns, formed during an oral glucose tolerance test. Insulin resistance develops slowly over a period of decades. This means that the high insulin causes the high blood glucose (symptom of the disease). In part 2, we explored fasting insulin, the most important test most doctors aren’t ordering. Kraft used it simultaneously with his glucose tolerance tests for decades. requires an immuno assay) - Dr Kraft was lucky in that he had full access to insulin assays to conduct his trials, but given how life-changing diabetes can be, aren't UK patients worth it too ? Healthy Range: 1.0 (0.5–1.4) Less than 1.0 means you are insulin-sensitive which is optimal. (It’s only a problem when glucose is high.) Save my name, email, and website in this browser for the next time I comment. This leaves glucose outside in the blood while the cell experiences internal starvation. The lab sent me back the results on Monday, November 2nd. [18] [19] This pattern indicates hyperinsulinemia. The train is already full, so passengers are left waiting on the platform. A Kraft Insulin Assay, which measures insulin response over time to a certain amount of glucose, will give you an accurate idea of whether you’re insulin resistant, however these tests are expensive and fairly hard to obtain. Test kit includes laboratory fee. In case you don’t know what the OGTT is, let’s start there. All Rights Reserved. The Kraft insulin survey builds on the information provided by OGTT. No additional laboratory cost and tax. (Being home due to covid made that easier!). If you’ve never heard of the Kraft test, don’t worry; you’re not alone. Pattern 1 – Metabolically healthy: In response to a glucose load, the insulin level rises quickly, but moderately, and it comes back down relatively quickly. In response to a glucose load, insulin barely budges, but glucose reaches diabetic levels (possibly as high as ≥300mg/dL). The Kraft Test. And what if your fasting sugar and fasting insulin are both normal, but you suspect your unresolved health issues could be due to high insulin at other times of the day? But if you have normal blood sugars, then you may still be at risk of diabetes (pre-diabetes). The action of insulin to increase DNL is not being resisted, but enhanced. Small amounts of it are normally released after each meal to help transport glucose into the body’s cells, where it is needed for energy production. In the train analogy, the conductor’s signal fails to open the subway doors fully so passengers are unable to pass through. Learn how your comment data is processed. To compensate, insulin levels increase and like the Japanese Subway Pushers, tries to push more glucose into the cell by force. As he wrote in his book, Diabetes Epidemic & You, “There are far too many who are told, ‘Don’t worry, your fasting blood sugars are normal.’” And indeed, many people do have normal fasting blood sugar, but that’s only thanks to sky-high insulin. This test looks at patterns of insulin response rather than a strict cut-off point for glucose. Therefore, the proper treatment of T2D is to LOWER INSULIN. For people concerned with achieving and maintaining optimal health, few things are more important than healthy gluco-regulation—that is, your body’s blood glucose and insulin levels, and how they respond to the foods you eat. Mein Insulin schießt eine Stunde nach der Glucose-Challenge geradezu in die Höhe. Which means just like you’d check your glucose levels at 30, 60, 90 and 120 minutes, you would also check your insulin levels to see if they followed a normal response. Fat backs up in the liver, an organ not designed for fat storage. Understanding this new paradigm is critical. Tests such as HOMA have been validated against the clamp test. (Occasionally some labs will include tests at the 30 and 90-minute marks as well.). Insulin’s action on glucose is being resisted. Let’s think about the liver cell. Joseph Kraft is a medical doctor who measured over 14,000 oral glucose tolerance tests in his lifetime. All the passengers go into the train without problems and the platform is empty as the train pulls out. High insulin has the same pathology as diabetes, without any warnings from the pathetically lagging FGB and the inadequate A1c test! (which are formed when insulin increases.) But what was the initial cause? When the gate opens for glucose to enter, it is unable to do so. It can improve your blood sugars, blood pressure and metabolic health, lowering your risk of heart disease, stroke and cancer. Dr Kraft’s analysis suggested that 80% of people are using excess insulin to suppress glucose, while a normal glucose screen would suggest that only two-thirds of people are fine. Dr. Kraft spent more than a quarter century devoted to the study of glucose metabolism and blood insulin levels – collecting data in almost 15,000 people, aged 3 to 90 years old. If your fasting insulin is in the double digits, it’s a sure sign something is awry. Plus, you will be able to stop using your overpriced drugs or insulin shots… because you’ll reteach your body to regulate blood sugar on its own. How? I am thinking now to try high carb (In processed plant based ) low fat To see things are normal for insulin and glucose . Daher lautet die Maßgabe heute: In der Regel können alle Insuline unmittelbar vor dem Essen gespritzt werden. test carried out (fasting glucose, 2-hour glycemic index, 3-hour glucose-insulin index, four-hour glycemic index or four-hour glucose-insulin index), and an abnormal value already made the test altered until its end. Copyright © 2020 Phase2Body, Inc. All Rights Reserved. When all insulin measurements are low and glucose is elevated, this pattern is suggestive of type 1 diabetes. 52 – How Megan Ramos of The Fasting Method is Using Intermittent Fasting and Heads Up’s Remote Monitoring Technology to Help Patients Worldwide Reach Their Health Goals, Measuring Ketones: The Difference Between Testing Breath and Blood, Low-carb Lab Testing — Part 7 — The Kraft Test (Hyperinsulinemia), Features | Self Tracking | Stories of Transformation, Self Tracking | Stories of Transformation, Instead of only two hours, the test is extended to five hours. (After all, why would you want to drink 75+ grams of liquid glucose, even if you’re not on a low carb diet?) Hyperinsulinemia. Without Dr. Kraft's incredible work, I would not have continued to follow dietary lifestyle changes, lowering my … On the other, insulin’s effect on DNL is enhanced. Yes! Glucose response is normal, but insulin is elevated higher than normal, and it remains elevated for a prolonged amount of time. Wimbledon Clinic of Natural Medicine. The insulin resistance creates hyperinsulinemia, the very thing that created it. When we don’t eat, or fast, glucose leaves. by Heads Up Health | Jan 30, 2018 | Self Tracking | 4 comments. But that’s not the sole possibility. This may explain the popularity of fasting meas- ures such as homeostasis modal assessment (HOMA). For many health reasons, losing weight is important. The same situation can happen in the cell, particularly the liver. I am also in the same situation . Insulin resistance can be determined by measuring insulin response to a standard glucose load over a 5 hour period and plotting the Insulin Response curves – which is precisely what Dr. Joseph R. Kraft MD, who was Chairman of the Department of Clinical Pathology and Nuclear Medicine, St. Joseph Hospital, Chicago, until his retirement. But what should you do if your fasting insulin level is normal, but you think you have signs and symptoms of chronic hyperinsulinemia? Healthy Range: 1.0 (0.5–1.4) Less than 1.0 means you are insulin-sensitive which is optimal. As glucose is left outside the cell, in the blood, the body produces more insulin for reinforcement. This makes perfect physiologic sense. But according to the ‘overflow’ model, things look like this. Excellent presentation close to individual experience and so practical/logical apart from being scientific. 2) Rabasa-Lhoret R, Bastard JP, Jan V, et. The lab listed me as Pattern 1 due to normal insulin, but clearly the pancreas isn’t responding to evening glucose levels, and this isn’t normal. The cell is now insulin resistant. By including insulin measurements and extending the test to five hours, what Kraft discovered was nothing short of mind-blowing. We emphasized that besides just measuring your glucose, it’s imperative to keep track of your insulin levels. This extra insulin helps push more glucose into the cell, but it becomes ever harder to put more and more glucose inside. Pattern 5 – Insulinopenic (low insulin): Fasting insulin is very low. But people with normal OGTT may still have an abnormal insulin response. For more information, please view our privacy policy. BUT: it’s been suggested that people who’ve been following a low carb or ketogenic diet for a while should “carb up” for a week or so to prepare for an OGTT or Kraft test. The vicious cycle goes round and round, worsening with each iteration. C-Peptide is a blood test, to determine how much insulin your body is … We call it the pre-pre-diabetes test, because it measures your insulin levels, which typically becomes imbalanced long before glucose or HbA1C levels. Often called TZDs for short, this oral diabetes medication has the ability to decrease insulin resistance. With persistently high insulin levels, glucose keeps entering the liver cell. It’s considered the best way of actually determining what your insulin resistance is. Even your Bristol stool score! Without Dr. Kraft's incredible work, I would not have continued to follow dietary lifestyle changes, lowering my carbohydrate daily levels to , Once you know for sure how your body responds, you can put that data to work for you and let it guide you onto a path to better health. Past posts on our blog have explained how to interpret various lab tests for people on low carb diets, such as fasting glucose and hemoglobin A1c. The gold standard test for insulin resistance is the hyperinsulinaemia-euglycaemia clamp test, which assesses the glucose uptake rate. Dr. Kraft, a clinical pathologist, ran 3,650 glucose-insulin tolerance tests. In our train analogy, the train pulls into the station, receives the signal to open the doors, but no passengers enter the train. Many of his tests were ran for only three hours or four hours. Think about this. Copyright © 2021 The Fasting Method. You consume the liquid glucose, and then your glucose and insulin are both measured at the 30-minute mark, and then again at one hour, two, three, four, and five hours. Low insulin 2.5,28,15 but high glucose 93,155,136. This pattern indicates hyperinsulinemia. Fasting insulin level is normal, and the peak level is reached at 30-60 minutes. There are those, for example that claim dietary fat causes IR, others say vegetable oil, inflammation, oxidative stress, genes etc. In response to a glucose load, the already elevated baseline insulin level skyrockets, takes a very long time to come back down, and when it does eventually come down, it comes down only to the baseline, which was already abnormally high. Multiple-sampled glucose tolerance tests required to produce the Kraft and Hayashi patterns are resource-in-tensive. As the train pulls out, many passengers are left on the platform, unable to enter the train. How? The only logical treatments, therefore are to. One solution is simply to hire “subway pushers” to shove people into the trains. This can cause serious health problems. Hyperinsulinemia leads to insulin resistance, which leads back to more hyperinsulinemia. In the standard ‘internal starvation’ model, some unknown thing (inflammation, oxidative stress etc.) A really great explanation. That’s all you need to know to reverse type 2 diabetes. With more than 35 years experience in Natural Therapies and treatments, Wimbledon Clinic of Natural Medicine offers a unique tailored combination of natural treatment and medicine that have been specifically developed by … This happens in the liver cell, with the same level of insulin and the same insulin receptors. On the one hand, the cell is resistant to insulin’s effect on glucose. The disease is HYPERINSULINEMIA. This is a delayed peak, and it takes even longer to come back to baseline. They are left outside on the platform, while the inside of the train is relatively empty. While these practices died out in North America, they still exist in Japan, where they are called “passenger arrangement staff”. With these two small changes, the Kraft test provides a staggering amount of information you won’t get from a standard OGTT. Be forewarned, this test takes a long time and you have to get a LOT of Blood spots, 5 large blood spots per test! To describe the situation of normal glucose with high insulin, Dr. Kraft coined the phrases diabetes in-situ, and occult diabetes—occult meaning “hidden”—the diabetes (that is, the high glucose), is hidden, or masked, by the high insulin. It is a terrific way to reveal the dynamic between your baseline (fasting) blood sugar and the responsive hormone insulin. The Fasting Insulin Test We said it last time, and it’s worth repeating: A fasting insulin test is the most important test your doctor probably isn’t ordering. This year I’ve had mycotoxins and headaches, so aside from ridding myself of that I’ve really focused on diet. Table 3 3 presents the distribution of each test per participant for both Kraft and Hayashi insulin response patterns. Not because the door failed to open, but because the train is already overflowing. That’s where we can help. Ein noch genaueres Bild liefert der Prädiabetes-Index nach Dr. Kraft. Für diese Empfehlung gibt es jedoch keinen wissenschaftlichen Beleg. Our holistic approach to healthcare combined with the advanced diagnostic tests and rapid access to accredited laboratories throughout Europe means you can be reassured that we give you a tailored treatment specifically design for your conditions and body system, to improve and better your health, naturally.